Tsosie is a Willard H. Pedrick Distinguished Research Scholar, Faculty Fellow in the Center for Law and Global Affairs, and an Affiliate Professor in the American Indian Studies Program at ASU. She teaches in the areas of Indian law, Property, Bioethics, and Critical Race Theory, as well as seminars in International Indigenous Rights and in the College's Tribal Policy, Law, and Government Master of Laws program. She has written and published widely on doctrinal and theoretical issues related to tribal sovereignty, environmental policy and cultural rights, and is the author of many prominent articles dealing with cultural resources and cultural pluralism. Tsosie also is the co-author with Robert Clinton and Carole Goldberg of a federal Indian law casebook. Her current research deals with Native rights to genetic resources. Tsosie annually speaks at several national conferences on tribal sovereignty, self-determination, and tribal rights to environmental and cultural resources.