Tsosie teaches in the areas of Indian law, Property, Bioethics, and Critical Race Theory, as well as seminars in International Indigenous Rights and in the College's Tribal Policy, Law, and Government Master of Laws program. She has written and published widely on doctrinal and theoretical issues related to tribal sovereignty, environmental policy and cultural rights, and is the author of many prominent articles dealing with cultural resources and cultural pluralism. She also is the co-author with Robert Clinton and Carole Goldberg of a federal Indian law casebook. Her current research deals with Native rights to genetic resources.
Tsosie, who is of Yaqui descent, has worked extensively with tribal governments and organizations and serves as a Supreme Court Justice for the Fort McDowell Yavapai Nation.